#476 – Dr. Mark Mofid, Founder at SYLKE

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Episode Details:

Join us on the latest episode, hosted by Jared S. Taylor! Our Guest: Dr. Mark Mofid, Founder at SYLKE.

What you’ll get out of this episode:

  • Inspiration Behind SYLKE: Dr. Mofid’s dissatisfaction with outdated wound closure technologies like sterile strips led to creating a modern solution.
  • Challenges Overcome: From assembling teams to navigating hospital contracts, SYLKE faced and tackled significant hurdles.
  • Innovative Product Features: SYLKE offers a skin-friendly, silicone-based adhesive designed to supplant older, less effective technologies.
  • Future Focus Areas: Developing specialized dressings for orthopedic surgery and burn care while rethinking everyday bandages.
  • Advice for Aspiring Innovators: Dr. Mofid emphasizes creativity and questioning the status quo in medical entrepreneurship.

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A Vision Born from Dissatisfaction

Dr. Mark Mofid, a plastic surgeon and faculty member at Johns Hopkins, founded SYLKE to address a glaring need in wound care. Reflecting on outdated technologies, such as the 60-year-old sterile strip, Dr. Mofid found it unacceptable that modern surgeries ended with inadequate closure methods prone to failure. His mission? To develop a skin-friendly, silicone-based wound closure device that adapts to post-surgical swelling and motion—a stark improvement over traditional options.

Challenges on the Path to Innovation

As a first-time entrepreneur, Dr. Mofid faced obstacles typical of pioneering ventures. From assembling a team to securing funding and navigating complex hospital contracts, the journey demanded resilience and strategy. Despite these hurdles, SYLKE is now available in 100 U.S. hospital systems within its first year on the market, a testament to its effectiveness and potential.

Revolutionizing Surgical Outcomes

SYLKE’s products aim to replace two-octyl cyanoacrylate adhesives like Dermabond, which Dr. Mofid critiques as outdated and unsafe due to formaldehyde byproducts. With a focus on safety and versatility, SYLKE’s solutions meet the unique demands of diverse surgeries, from delicate plastic procedures to high-motion areas like joints.

Expanding Horizons

Looking forward, SYLKE plans to develop tailored solutions for orthopedic surgeries, including knee arthroplasty dressings, and innovations for burn care and lacerations. The company also envisions transforming everyday wound care with waterproof bandages that maintain skin edge alignment—eliminating daily changes and discomfort.

Advice for Aspiring Medical Entrepreneurs

Dr. Mofid encourages medical professionals to maintain their creativity and question established norms. He underscores the importance of addressing even “low-tech” gaps in healthcare, highlighting that impactful innovation doesn’t always require cutting-edge robotics or AI.

Through his work at SYLKE, Dr. Mofid demonstrates that a blend of ingenuity, persistence, and practicality can create life-changing advancements in medicine.

Finally, to learn more about our guest and their company please use the links below:

Company LinkedInCompany Website – 


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